Win a Licence of microDimensions Outspace for Stereological Volume Estimation

Are you tired of overcomplicated stereology applications? Would you like to speed up volume estimation from a set of histology sections? With microDimensions Outspace™ you are guided by an intuitive wizard to quantify volumes based on the Cavalieri estimator. Save up to 30% time in your studies due to increased automation compared to conventional stereology software!

With microDimensions Outspace you can significantly speed up your lab work – let the software automatically detect and align all sections on your glass slides instead of struggling with rotating or flipping them manually. Selection of specific sections, definition of regions of interest, and volume estimation is all bundled in microDimensions Outspace: a solution that can be seamlessly integrated into your workflow, from the available image set to the final result export.

For a chance to win a free license for microDimensions Outspace worth USD 4,500,

register now for the raffle! *

Get Outspace now to save clicks and time with computer-assisted stereology.

* For Research Use Only. Not for use in diagnostic procedures. Entries are collected during the entry period from June 15, 2015, 0:01am EDT to July 31, 2015, 11:59pm PDT. An entry requires the submission of the full name, e-mail address, telephone number, organization, country, and answering up to five short questions using the form provided at micro-dimensions.com/events/2015/6/15/outspace-raffle. Only one submission per person is allowed. Employees, business partners, or competitors of microDimensions are not allowed to participate. Among all entries one winner will be determined by random draw. The winner will be notified by e-mail and will receive a license for microDimensions Outspace (subject to the end user license agreement available at micro-dimensions.com/eula) that is valid from September 1, 2015 to February 29, 2016 (corresponding to a value of USD 4,500) at no cost and with no automatic extension or any other obligations. The prize cannot be claimed in cash.

Memorial Sloan Kettering Cancer Center Uses Voloom for 3D Reconstruction of Immunofluorescence Serial Sections

In a recent publication, Fujisawa et al. [1] describe how they used Voloom to reconstruct immunofluorescently stained adjacent sections. Apart from visualizing geometric structures, this enables them to study and analyze the presence and interactions of multiple specific proteins and molecules in high resolution (using Imaris from Bitplane). This would have been very challenging in tissue blocks, thick sections, or whole mount samples.

Reconstructed brain region showing complex interactions between blood vessels (red, CD31), cancer cells (green, GFP), and astrocytes (white, GFAP)
[Image courtesy of Sho Fujisawa, Memorial Sloan Kettering Cancer Center]

Reconstructed CD31-positive blood vessel (red) and spot detection of pMAPK-positive cells with color-coded distance information
[Image courtesy of Sho Fujisawa, Memorial Sloan Kettering Cancer Center]

CD31 stained blood vessels in reconstructed myxofibrosarcoma
[Image courtesy of Sho Fujisawa, Memorial Sloan Kettering Cancer Center]

In their study they focused on high automation of the processing, staining, imaging, and alignment of sectioned paraffin embedded samples. Their method enables the visualization, analysis, as well as observation of the clear separation, localization and interaction of multiple antigens, proteins, and molecules in tissue samples with a thickness of more than 100 microns.

Thick sections (top) and reconstructed serial sections (bottom) of a mouse heart region (left) and mouse brain region (right) in comparison, showing CD31-positive vasculature (red), spot detected Ki67-positive nuclei (green), and DAPI (blue). In particular for the brain region the Ki67 signal is much more extensive in the serial sections (bottom right) than in the thick section (top right).
[Image courtesy of Sho Fujisawa, Memorial Sloan Kettering Cancer Center]

More details can be found in their original article:

1. Sho Fujisawa, Dmitry Yarilin, Ning Fan, Mesruh Turkekul, Ke Xu, Afsar Barlas, and Katia Manova-Todorova, "Understanding 3-Dimensional World from 2-Dimensional Immunofluorescent Adjacent Sections," Analytical Cellular Pathology, vol. 2014, Article ID 784937, 2 pages, 2014. doi:10.1155/2014/784937

Free Whole Slide Viewer Zoom Gets Requested Features

microDimensions, global provider of state-of-the-art digital pathology software, today released Zoom 1.1. Zoom is microDimensions’ free of charge viewer for whole slide images from all major hardware vendors and supports an unlimited number of 8 and 16 bit channels. This update adds more intuitive navigation as well as snapshot capabilities to the fastest digital pathology viewer on the market.

microDimensions Zoom now smartly reacts to user interactions. During panning and zooming an overview window shows where the current view is located inside the whole slide image. Next to the scale also the magnification of the objective lens is displayed. Furthermore, at any time a snapshot of the current view can be saved as JPEG, Bitmap, PNG, or TIFF image.

“Thanks to our fast growing user base we got a lot of valuable and useful feedback, which we took and will always take very seriously”, said Dr. Hauke Heibel, CTO of microDimensions. “This allowed us to quickly respond to all major requests with a more powerful, updated version of Zoom.”

For more information and to request a free copy of Zoom please visit the product page micro-dimensions.com/zoom.

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Meet us at these upcoming exhibitions:

• AACR Meeting, 18-22 April 2015, Philadelphia, PA, USA, booth #1636
• Digital Pathology Congress, 22-23 June 2015, San Diego, CA, USA, booth #4
• Digital Pathology Congress, 3-4 December 2015, London, UK, booth #19

To schedule an appointment at one of these exhibitions, please send an e-mail with your preferred date and time to sales@micro-dimensions.com.

microDimensions Debuts Free Whole Slide Viewer Zoom

microDimensions, global provider of state-of-the-art digital pathology software, today released Zoom, the fastest, most versatile, and free of charge viewer for a plethora of whole slide image file formats.

microDimensions Zoom can display an unlimited number of channels of 8 bit and 16 bit data, no matter whether they were acquired by brightfield, electron microscope, fluorescence, or laser scanning systems. The software supports all major whole slide image formats from 3DHISTECH, Aperio, Hamamatsu, Huron, Leica, Nikon, Zeiss, and other widely-used (.ims, .jpeg, .mha, .nii, .tiff) file formats.

“Our digital pathology viewer Zoom is a lightweight piece of software to easily and quickly view, share, and discuss your cases”, said Dr. Martin Groher, CEO of microDimensions. “Even if you have multiple scanners or systems all with proprietary formats, Zoom will be at your fingertips, ready to visualize all of them at maximum speed.”

microDimensions Zoom boils down to what a digital pathology viewer is meant for:

• Visualization of whole slide images and confocal stacks
• Smooth panning, zooming, and scrolling of very large 2D and 3D images, also over an internal network
• Simple adjustment of rendering settings (brightness, contrast, gamma) and turning on/off of individual channels

For more information and to request a free copy of Zoom please visit the product page micro-dimensions.com/zoom.

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Meet us at these upcoming exhibitions:

• AACR Meeting, 18-22 April 2015, Philadelphia, PA, USA
• Digital Pathology Congress, 22-23 June 2015, San Diego, CA, USA
• Digital Pathology Congress, 3-4 December 2015, London, UK

To schedule an appointment at one of these exhibitions, please send an e-mail with your preferred date and time to sales@micro-dimensions.com.

microDimensions Enhances Stereology and 3D Histology Applications

microDimensions today announced new versions of its digital pathology applications Outspace™ and Voloom®. The updates address some of the most important features requested by its customers and are available to all clients with an active maintenance plan.

Outspace significantly accelerates the process of unbiased volume estimation through the use of computer-assisted stereology based on Cavalieri’s principle. It comes now in version 1.1 and

• supports editing all sections during reconstruction,

• allows to enable and disable all Cavalieri crosses within the current region of interest,

• features an overview image to improve user navigation and orientation,

• consumes less system memory,

• and has an improved graphical user interface during analysis.

For more information please visit the Outspace product page micro-dimensions.com/outspace.

Voloom reconstructs serial sections and facilitates 3D histology in a matter of minutes. Version 2.3 will be released on 9 March 2015 and

• supports Carl Zeiss Axio Scan.Z1 .czi whole slide images,
• allows to manually specify the image modality in the reconstruction wizard,
• exports the actual number of stains during stained Bitplane Imaris .ims export,
• and improves background color estimation on fluorescence data sets.

For more information please visit the Voloom product page micro-dimensions.com/voloom.

We sincerely invite you to register for one of our upcoming free webinars on Voloom in order to get an insight into its features and capabilities. The next demo webinars are scheduled for:

•  Monday, 9 March 2015, 10am PDT / 1pm EDT / 18:00 CET
• Wednesday, 15 April 2015, 8am PDT / 11am EDT / 17:00 CEST
• Tuesday, 26 May 2015, 9:00 CEST / 16:00 JST

Register now at micro-dimensions.com/webinars.

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Meet us at these upcoming exhibitions:

• AACR Meeting, 18-22 April 2015, Philadelphia, PA, USA
• Digital Pathology Congress, 22-23 June 2015, San Diego, CA, USA
• Digital Pathology Congress, 3-4 December 2015, London, UK

To schedule an appointment at one of these exhibitions, please send an e-mail with your preferred date and time to sales@micro-dimensions.com.

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About microDimensions:

microDimensions is a privately held company, which develops and distributes software solutions for microscopic image processing and analysis. Their cutting-edge software solutions Voloom® and Outspace™ are the world’s fastest tools for convenient and accurate 3D histology reconstruction and stereology, respectively. They enable pharmaceutical and biotech companies to accelerate early drug testing and allow research organizations to gain new insights into cancer, multiple sclerosis, chronic infections, and other diseases.

Contact:

Dr. Marco Feuerstein
COO, microDimensions
pr@micro-dimensions.com
+49 89 1894253 34

microDimensions Launches Outspace: Speedy Stereology

Munich, 3 February 2015

microDimensions, global provider of the world’s most powerful 3D histology reconstruction software Voloom®, today added Outspace™ to its digital pathology image analysis portfolio, the fastest and most easy-to-use stereology software for Cavalieri volume estimation from histology whole slide images.

microDimensions Outspace pairs our patent pending image registration techniques with an intuitive user interface to provide one of the fastest stereology software solutions available worldwide. It automatically aligns tissue samples distributed over multiple sections and propagates and pre-labels regions of interest so that manual labeling is reduced to a minimum. The software supports common whole slide images and is compatible with 3DHISTECH, Aperio, Bitplane, Hamamatsu, Huron, Leica, Nikon, Zeiss, and generic (.tiff, .jpeg) file formats, no matter whether they were acquired by brightfield, fluorescence, or laser scanning systems.

Our stereology software Outspace can speed up our customers’ workflows by more than 30 percent in comparison to other software solutions, said Dr. Martin Groher, CEO of microDimensions. We put a lot of development effort into a streamlined workflow and a clear user interface for Outspace, so that our customers can concentrate on their expertise and are able to reach their research and business goals faster.

microDimensions Outspace helps life science, healthcare, pharmaceutical, and biotech scientists and researchers in drug discovery, preclinical studies, and other application areas to perform unbiased tissue volume estimation according to Cavalieri’s principle. As only basic stereology knowledge is required and random sampling and probing is ensured by the software, users can set out to work right away. Starting from an integrated study manager, all study information can be collected, processed, and its results exported to Microsoft Excel.

For more information please visit the Outspace product page micro-dimensions.com/outspace.

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Meet us at these upcoming exhibitions:

• Molecular Med Tri-Con, 16-18 February 2015, San Francisco, CA, USA
  Our visitors will receive $200 off for commercial attendees or $100 off for academic, government and hospital-affiliated attendees.* Be sure to mention priority code "MDICOP" to receive this exclusive discount.
• AACR Meeting, 18-22 April 2015, Philadelphia, PA, USA
• Digital Pathology Congress, 22-23 June 2015, San Diego, CA, USA

To schedule an appointment at one of these exhibitions, please send an e-mail with your preferred date and time to sales@micro-dimensions.com.

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About microDimensions:
microDimensions is a privately held company, which develops and distributes software solutions for microscopic image processing and analysis. Their cutting-edge software solutions Voloom® and Outspace™ are the world’s fastest tools for convenient and accurate 3D histology reconstruction and stereology, respectively. They enable pharmaceutical and biotech companies to accelerate early drug testing and allow research organizations to gain new insights into cancer, multiple sclerosis, chronic infections, and other diseases.

Contact:
Dr. Marco Feuerstein
COO, microDimensions
pr@micro-dimensions.com
+49 89 1894253 34

* You must mention priority keycode MDICOP to receive this exclusive discount. Alumni, Twitter, LinkedIn, Facebook or any other promotional discounts cannot be combined. Discounts not applicable on Event Short Courses. This discount does not apply to previously registered attendees.

We Have a Winner!

Raffle for a Voloom License

Thanks to everyone who participated in our recent draw for a 6 month license of microDimensions Voloom! The winner of a free license for Voloom, the fastest and most versatile software for histology 3D reconstruction, has been drawn. Among all the 29 entries we received from the announcement in mid-December to the deadline on January 20, we determined the winner by random draw.1 The lucky owner of a 6 month license is

Jae-Kwang Jung, Assistant Professor at the Kyungpook National University, South Korea.

In case you are not the winner don't be disappointed. Do not miss the chance to see your slides in 3D - just visit the Voloom product page to request a fully functional free trial version and open up new perspectives for your research.

microDimensions Voloom – 3D Histology Made Simple

microDimensions Voloom is the fastest and most versatile software for the 3D reconstruction and analysis of serially sectioned histology specimens. Voloom 2.2 was released in November 2014 and it

• contains several improvements for customers working with (non-WSI) camera microscopes,
• features maximum intensity projection renderings for fluorescence as well as color-deconvolved brightfield images,
• allows the export of color-deconvolved image channels, and
• automatically applies the Pannoramic Viewer's brightness, contrast, and gamma settings when reading MRXS files.

We cordially invite you to register for one of our upcoming free webinars on Voloom in order to get an insight into its features and capabilities. Please register at micro-dimensions.com/webinar.

Topics covered:

• 3D histology reconstruction of serial sections (bright field and fluorescence)
• Navigation through 3D histology data sets
• Tumor volume quantification
• 3D visualization
• Stain separation by color deconvolution
• Processing and loading of confocal whole slide images
• New features in Voloom 2.2
• Q&A

The next demo webinars are scheduled for:

• Thursday, 29 January 2015, 10:00 CET / 18:00 JST
• Monday, 9 March 2015, 10am PDT / 1pm EDT / 18:00 CET
• Wednesday, 15 April 2015, 8am PDT / 11am EDT / 17:00 CEST 

Register now at micro-dimensions.com/webinar.

More information

For more information and to obtain a fully functional trial version please visit micro-dimensions.com/voloom.

Meet us at these upcoming exhibitions:

• Molecular Med Tri-Con, 16-18 February 2015, San Francisco, CA, USA
  Our visitors will receive $200 off for commercial attendees or $100 off for academic, government and hospital-affiliated attendees.2 Be sure to mention priority code "MDICOP" to receive this exclusive discount.
• AACR Meeting, 18-22 April 2015, Philadelphia, PA, USA
• Digital Pathology Congress, 22-23 June 2015, San Diego, CA, USA

To schedule an appointment at one of these exhibitions, please send an e-mail with your preferred date and time to sales@micro-dimensions.com.

About microDimensions:

microDimensions is a privately held company, which develops and distributes software solutions for microscopic image processing and analysis. Its cutting-edge software Voloom is the world’s fastest tool for convenient and accurate 3D histology reconstruction. It enables pharmaceutical and biotech companies to accelerate early drug testing, allows research organizations to gain new insights into cancer, multiple sclerosis, chronic infections, and other diseases.

Contact:

Andreas Keil, Ph.D.
VP Business Development
microDimensions
Tel.: +49 89 189 425 333

1. microDimensions used Random.org as 3rd party service provider to perform the random draw. If you want to verify the results yourself, please enter the e-mail address you supplied for the raffle athttp://www.random.org/draws/details/?draw=25816. This web site allows you to confirm your participation and the drawing result.
2. You must mention priority keycode MDICOP to receive this exclusive discount. Alumni, Twitter, LinkedIn, Facebook or any other promotional discounts cannot be combined. Discounts not applicable on Event Short Courses. This discount does not apply to previously registered attendees.

New Features in microDimensions Voloom 2.2 - 3D Histology Made Simple

Voloom 2.2 will be released with on Wednesday, 5 November 2014, and is available to all customers with a current maintenance plan. This version

• contains several improvements for customers working with (non-WSI) camera microscopes,
• features maximum intensity projection renderings for fluorescence as well as color-deconvolved brightfield images,
• allows the export of color-deconvolved image channels,
• features a converter tool that creates Bitplane's Imaris .ims files from all supported WSI formats, and
• automatically applies the Pannoramic Viewer's brightness, contrast, and gamma settings when reading MRXS files.

We cordially invite you to register for one of our upcoming free webinars on Voloom in order to get an insight into its features and capabilities. Please register at micro-dimensions.com/webinar.

Topics covered:

• 3D histology reconstruction of serial sections (bright field and fluorescence)
• Navigation through 3D histology data sets
• Tumor volume quantification
• 3D visualization
• Stain separation by colour deconvolution
• Processing and loading of confocal whole slide images
• New features in Voloom 2.2
• Q&A

The next demo webinars are scheduled for:

• Wednesday, 5 November 2014, 9am PT / 12 noon ET / 18:00 CET
• Tuesday, 16 December 2014, 8am ET / 14:00 CET / 22:00 JST
• Thursday, 29 January 2015, 10:00 CET / 18:00 JST
• Monday, 9 March 2015, 10am PDT / 1pm EDT / 18:00 CET

Register now at micro-dimensions.com/webinar.

For more information and to obtain a fully functional trial version please visit micro-dimensions.com/voloom.

Also meet us at these upcoming exhibitions:

• Society for Neuroscience, 16–19 Nov 2014, Washington, D.C., booth #2903
• Digital Pathology Congress, 4-5 Dec 2014, London, UK
• Molecular Med Tri-Con, 16-18 Feb 2015, San Francisco, CA, USA

To schedule an appointment at one of these exhibitions, please send an e-mail with your preferred date and time to sales@micro-dimensions.com.

About microDimensions:
microDimensions is a privately held company, which develops and distributes software solutions for microscopic image processing and analysis. Its cutting-edge software Voloom is the world’s fastest tool for convenient and accurate 3D histology reconstruction. It enables pharmaceutical and biotech companies to accelerate early drug testing and allows research organizations to gain new insights into cancer, multiple sclerosis, chronic infections, and other diseases.

Contact:
Andreas Keil, Ph.D.
VP Business Development
microDimensions
Tel: +49 89 1894253 33
sales@micro-dimensions.com

Bitplane and microDimensions Announce Partnership to Bring Voloom to the Wider Life Sciences Market

Bitplane, an Oxford Instruments company and microDimensions announce a partnership to bring Voloom®, from microDimensions, to the wider life sciences market via the Bitplane sales channels.

Voloom is an intuitive and automated software solution for the alignment and reconstruction of whole slide scanner images (and other series of 2D images) of any size. Voloom enables the examination of tissue slices as a 3D volume thus revolutionizing the way users of whole slide imaging devices can see and interact with the entire 3D sample. Imaris natively reads Voloom output and can determine a number of key parameters (i.e. volume, shape, surface structure and many more quantitative measures).

The combination of Voloom and Imaris enables researchers who typically work with 2D serial sections (e.g. automated whole slide scanner or conventional microtome+microscope users) to complete quantitative analyses on 3D volumes. Initially both bright-field and fluorescence data are supported but in the mid-term more imaging modalities will be added to the workflow.

Luciano Lucas, Bitplane Product Manager: “Voloom’s speed and automation is remarkable. This tool, in combination with Imaris’ quantitative features, will greatly enhance the range of applications whole slide scanner users can complete. In addition, Voloom is a great way to convert classical 2D serial sections into 3D data blocks which Imaris can read and work with.”

Andreas Keil, microDimensions Product Manager: “Imaris is the de-facto standard for analyzing 3-dimensional microscopic data. Therefore, it is the natural tool for advanced post-processing and analysis of 3D volumes that were reconstructed using Voloom. Bringing together Imaris and Voloom will open up new opportunities for the microscopy imaging community when analyzing stacks of fluorescence and bright-field scans.”

Free Webinar on microDimensions Voloom - 3D Histology Made Simple

microDimensions Voloom is the fastest and most versatile software for the 3D reconstruction and analysis of serially sectioned histology specimens. Its intuitive reconstruction wizard allows for fast and easy reconstructions of histological volumes from serial sections. The reconstructed 3D data set can then be browsed and explored interactively, including looking at arbitrarily angled cut planes and volume renderings. Voloom also enables the user to obtain accurate and reproducible distance and volume measurements in 3D.

Please register now for a free webinar on microDimensions Voloom or download a free trial version.

The next demo webinars are scheduled for:

• Monday, 29 September 2014, 10:00 CEST / 17:00 JST
• Wednesday, 5 November 2014, 9am PT / 12pm ET / 18:00 CET
• Tuesday, 16 December 2014, 8am ET / 14:00 CET / 22:00 JST

Register now at micro-dimensions.com/webinar.

If you haven’t tried microDimensions Voloom yet, then please check out these features:

• Reading of whole slide images from major scanner manufacturers
• Support for Imaris® .ims files (import, reconstruction, and export)
• Intuitive reconstruction wizard, including automatic section separation and alignment
• Support of full zoom functionality in 3D including all scanned magnification levels
• Reconstruction of extremely large image stacks (more than 1000 sections)
• Color picking for user-defined stain separation (color deconvolution)
• Various rendering modes (“radiology view”, multi-planar reconstruction, direct volume rendering, maximum intensity projection)
• Quantitative analysis using distance measurements along arbitrary directions and volume quantification using segmentation

For more information and to obtain a fully functional trial version please visit micro-dimensions.com/voloom.

Also meet us at these upcoming exhibitions:

• Neuroscience, 16–19 November 2014, Washington, D.C., booth #2903

To schedule an appointment at one of these conferences, please send an e-mail with your preferred date and time to sales@micro-dimensions.com.

Meet microDimensions at one of the upcoming exhibitions

Meet microDimensions at these upcoming exhibitions:
• European Congress of Pathology (ECP), 31 Aug – 2 Sep 2014, London, booth #24
• International Microscopy Congress (IMC), 7 Sep – 12 Sep 2014, Prague, booth #71
• Neuroscience, 16 Nov – 19 Nov 2014, Washington D.C., booth #2903
For scheduling an appointment at one of these conferences, please send an e-mail with your preferred date and time to sales@micro-dimensions.com.

Voloom 2.1 with New Features

microDimensions Voloom is the fastest and most versatile software for the 3D reconstruction and analysis of serially sectioned histology specimens. Voloom 2.1 has just been released with exciting new features, especially for users that are also working with Imaris® (from Bitplane) or with fluorescence data. Register now for a free webinar on microDimensions Voloom or download the new version.

The new features in Voloom 2.1 are:

• Support for Imaris® .ims files (import, reconstruction, and export)
• Color picking for user-defined stain separation (color deconvolution)
• Improved contour detection on fluorescence data sets
• Information widget showing data of individual sections

For more information and to obtain a fully functional trial version
please visit the Voloom product page.

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The next demo webinars are scheduled for:

• Thursday, 21 August, 2014, 8am EDT / 14:00 CEST / 21:00 JST
• Monday, 29 September, 2014, 10:00 CEST / 17:00 JST
• Wednesday, 5 November, 2014, 9am PT / 12pm ET / 18:00 CET

Register now for one of these dates.

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Also meet us at these upcoming exhibitions:

• European Congress of Pathology (ECP), 31 Aug - 2 Sep 2014, London
• International Microscopy Congress (IMC), 7 Sep - 12 Sep 2014, Prague
• Neuroscience, 16 Nov - 19 Nov 2014, Washington D.C.Voloom 2.1 with New Features