In a recent publication, Fujisawa et al.  describe how they used Voloom to reconstruct immunofluorescently stained adjacent sections. Apart from visualizing geometric structures, this enables them to study and analyze the presence and interactions of multiple specific proteins and molecules in high resolution (using Imaris from Bitplane). This would have been very challenging in tissue blocks, thick sections, or whole mount samples.
In their study they focused on high automation of the processing, staining, imaging, and alignment of sectioned paraffin embedded samples. Their method enables the visualization, analysis, as well as observation of the clear separation, localization and interaction of multiple antigens, proteins, and molecules in tissue samples with a thickness of more than 100 microns.
More details can be found in their original article:
1. Sho Fujisawa, Dmitry Yarilin, Ning Fan, Mesruh Turkekul, Ke Xu, Afsar Barlas, and Katia Manova-Todorova, "Understanding 3-Dimensional World from 2-Dimensional Immunofluorescent Adjacent Sections," Analytical Cellular Pathology, vol. 2014, Article ID 784937, 2 pages, 2014. doi:10.1155/2014/784937